Research progress on the protective effects of fucoidan against intestinal mucosal barrier dysfunction (Review)
- Xia Qiu
- Fahe Wang
- Yimin Qin
- Zhanyi Sun
- Peili Shen
Affiliations: State Key Laboratory of Bioactive Seaweed Substances, Qingdao Bright Moon Seaweed Group Co., Ltd., Qingdao, Shandong 266400, P.R. China
- Published online on: December 27, 2021 https://doi.org/10.3892/ijfn.2021.24
Copyright: © Qiu
et al. This is an open access article distributed under the
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Commons Attribution License.
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The intestinal tract is one of the main organs responsible for digestion and absorption, and it also functions as a congenital barrier to maintain the homeostasis of the internal environment of the body. Damage to the intestinal mucosal barrier is closely related to the occurrence and development of a variety of diseases. As a natural food product, fucoidan has a number of biological activities. In recent years, it has been found that it exerts certain protective effects on intestinal physical, chemical, immune and microbial barriers. In the present review article, the role and mechanisms of action of fucoidan in protecting the intestinal mucosal barrier from damage are summarized and discussed. It is hoped that the information presented herein, may shed light onto the functions of fucoidan and may aid its use as a protective strategy against intestinal mucosal barrier dysfunction.