
Roles of small extracellular vesicles in the development, diagnosis and possible treatment strategies for hepatocellular carcinoma (Review)
- Authors:
- Shuyue Yang
- Jiaxin Wang
- Shidong Wang
- Anni Zhou
- Guiping Zhao
- Peng Li
-
Affiliations: Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China - Published online on: June 7, 2022 https://doi.org/10.3892/ijo.2022.5381
- Article Number: 91
-
Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
![]() |
![]() |
![]() |
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI | |
Petrick JL, Florio AA, Znaor A, Ruggieri D, Laversanne M, Alvarez CS, Ferlay J, Valery PC, Bray F and McGlynn KA: International trends in hepatocellular carcinoma incidence, 1978-2012. Int J Cancer. 147:317–330. 2020. View Article : Google Scholar : | |
Ringelhan M, McKeating JA and Protzer U: Viral hepatitis and liver cancer. Philos Trans R Soc Lond B Biol Sci. 372:201602742017. View Article : Google Scholar : PubMed/NCBI | |
Chen SQ, Li J, Wang D, Fung H, Wong LY and Zhao L: The hepatitis B epidemic in China should receive more attention. Lancet. 391:15722018. View Article : Google Scholar : PubMed/NCBI | |
Sarin SK, Kumar M, Eslam M, George J, Al Mahtab M, Akbar SMF, Jia J, Tian Q, Aggarwal R, Muljono DH, et al: Liver diseases in the Asia-pacific region: A lancet gastroenterology & hepatology commission. Lancet Gastroenterol Hepatol. 5:167–228. 2020. View Article : Google Scholar : | |
Zhao C, Xing F, Yeo YH, Jin M, Le R, Le M, Jin M, Henry L, Cheung R and Nguyen MH: Only one-third of hepatocellular carcinoma cases are diagnosed via screening or surveillance: A systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 32:406–419. 2020. View Article : Google Scholar | |
Wu G, Wu J, Wang B, Zhu X, Shi X and Ding Y: Importance of tumor size at diagnosis as a prognostic factor for hepatocellular carcinoma survival: A population-based study. Cancer Manag Res. 10:4401–4410. 2018. View Article : Google Scholar : PubMed/NCBI | |
Johnstone RM, Adam M, Hammond JR, Orr L and Turbide C: Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem. 262:9412–9420. 1987. View Article : Google Scholar : PubMed/NCBI | |
Chen W, Mao Y, Liu C, Wu H and Chen S: Exosome in hepatocellular carcinoma: An update. J Cancer. 12:2526–2536. 2021. View Article : Google Scholar : PubMed/NCBI | |
Chang W, Xiao D, Fang X and Wang J: Phospholipids in small extracellular vesicles: Emerging regulators of neurodegenerative diseases and cancer. Cytotherapy. 24:93–100. 2022. View Article : Google Scholar | |
Sun F, Wang JZ, Luo JJ, Wang YQ and Pan Q: Exosomes in the oncobiology, diagnosis, and therapy of hepatic carcinoma: A new player of an old game. Biomed Res Int. 2018:27474612018. View Article : Google Scholar : PubMed/NCBI | |
Wen SW, Lima LG, Lobb RJ, Norris EL, Hastie ML, Krumeich S and Möller A: Breast cancer-derived exosomes reflect the cell-of-origin phenotype. Proteomics. 19:e18001802019. View Article : Google Scholar : PubMed/NCBI | |
Wang S, Xu M, Li X, Su X, Xiao X, Keating A and Zhao RC: Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties. J Hematol Oncol. 11:822018. View Article : Google Scholar : PubMed/NCBI | |
Zheng X, Hermann DM, Bähr M and Doeppner TR: The role of small extracellular vesicles in cerebral and myocardial ischemia-molecular signals, treatment targets, and future clinical translation. Stem Cells. 39:403–413. 2021. View Article : Google Scholar : PubMed/NCBI | |
Zhang L, He F, Gao L, Cong M, Sun J, Xu J, Wang Y, Hu Y, Asghar S, Hu L and Qiao H: Engineering exosome-like nanovesicles derived from asparagus cochinchinensis can inhibit the proliferation of hepatocellular carcinoma cells with better safety profile. Int J Nanomedicine. 16:1575–1586. 2021. View Article : Google Scholar : | |
Kim OY, Lee J and Gho YS: Extracellular vesicle mimetics: Novel alternatives to extracellular vesicle-based theranostics, drug delivery, and vaccines. Semin Cell Dev Biol. 67:74–82. 2017. View Article : Google Scholar | |
Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, et al: Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 7:15357502018. View Article : Google Scholar | |
Murphy DE, de Jong OG, Brouwer M, Wood MJ, Lavieu G, Schiffelers RM and Vader P: Extracellular vesicle-based therapeutics: Natural versus engineered targeting and trafficking. Exp Mol Med. 51:1–12. 2019. View Article : Google Scholar : PubMed/NCBI | |
Aslan C, Maralbashi S, Salari F, Kahroba H, Sigaroodi F, Kazemi T and Kharaziha P: Tumor-derived exosomes: Implication in angiogenesis and antiangiogenesis cancer therapy. J Cell Physiol. 234:16885–16903. 2019. View Article : Google Scholar : PubMed/NCBI | |
Antimisiaris SG, Mourtas S and Marazioti A: Exosomes and exosome-inspired vesicles for targeted drug delivery. Pharmaceutics. 10:2182018. View Article : Google Scholar | |
Tian X, Shen H, Li Z, Wang T and Wang S: Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment. J Hematol Oncol. 12:842019. View Article : Google Scholar : PubMed/NCBI | |
Hessvik NP and Llorente A: Current knowledge on exosome biogenesis and release. Cell Mol Life Sci. 75:193–208. 2018. View Article : Google Scholar : | |
Doyle LM and Wang MZ: Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis. Cells. 8:7272019. View Article : Google Scholar : | |
Farooqi AA, Desai NN, Qureshi MZ, Librelotto DRN, Gasparri ML, Bishayee A, Nabavi SM, Curti V and Daglia M: Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds. Biotechnol Adv. 36:328–334. 2018. View Article : Google Scholar | |
Li X, Wang Y, Wang Q, Liu Y, Bao W and Wu S: Exosomes in cancer: Small transporters with big functions. Cancer Lett. 435:55–65. 2018. View Article : Google Scholar : PubMed/NCBI | |
Xie JY, Wei JX, Lv LH, Han QF, Yang WB, Li GL, Wang PX, Wu SB, Duan JX, Zhuo WF, et al: Angiopoietin-2 induces angiogenesis via exosomes in human hepatocellular carcinoma. Cell Commun Signal. 18:462020. View Article : Google Scholar : PubMed/NCBI | |
Zhao Z, Yang S, Zhou A, Li X, Fang R, Zhang S, Zhao G and Li P: Small extracellular vesicles in the development, diagnosis, and possible therapeutic application of esophageal squamous cell carcinoma. Front Oncol. 11:7327022021. View Article : Google Scholar : PubMed/NCBI | |
Yu S, Cao H, Shen B and Feng J: Tumor-derived exosomes in cancer progression and treatment failure. Oncotarget. 6:37151–37168. 2015. View Article : Google Scholar : PubMed/NCBI | |
Greening DW, Xu R, Ji H, Tauro BJ and Simpson RJ: A protocol for exosome isolation and characterization: Evaluation of ultra-centrifugation, density-gradient separation, and immunoaffinity capture methods. Methods Mol Biol. 1295:179–209. 2015. View Article : Google Scholar | |
Vaswani K, Koh YQ, Almughlliq FB, Peiris HN and Mitchell MD: A method for the isolation and enrichment of purified bovine milk exosomes. Reprod Biol. 17:341–348. 2017. View Article : Google Scholar : PubMed/NCBI | |
Yugawa K, Yoshizumi T, Mano Y, Itoh S, Harada N, Ikegami T, Kohashi K, Oda Y and Mori M: Cancer-associated fibroblasts promote hepatocellular carcinoma progression through downregulation of exosomal miR-150-3p. Eur J Surg Oncol. 47:384–393. 2021. View Article : Google Scholar | |
Nakano T, Chen IH, Wang CC, Chen PJ, Tseng HP, Huang KT, Hu TH, Li LC, Goto S, Cheng YF, et al: Circulating exosomal miR-92b: Its role for cancer immunoediting and clinical value for prediction of posttransplant hepatocellular carcinoma recurrence. Am J Transplant. 19:3250–3262. 2019. View Article : Google Scholar : PubMed/NCBI | |
Moh-Moh-Aung A, Fujisawa M, Ito S, Katayama H, Ohara T, Ota Y, Yoshimura T and Matsukawa A: Decreased miR-200b-3p in cancer cells leads to angiogenesis in HCC by enhancing endothelial ERG expression. Sci Rep. 10:104182020. View Article : Google Scholar : PubMed/NCBI | |
Fu X, Liu M, Qu S, Ma J, Zhang Y, Shi T, Wen H, Yang Y, Wang S, Wang J, et al: Exosomal microRNA-32-5p induces multidrug resistance in hepatocellular carcinoma via the PI3K/Akt pathway. J Exp Clin Cancer Res. 37:522018. View Article : Google Scholar : PubMed/NCBI | |
Tang J, Li Y, Liu K, Zhu Q, Yang WH, Xiong LK and Guo DL: Exosomal miR-9-3p suppresses HBGF-5 expression and is a functional biomarker in hepatocellular carcinoma. Minerva Med. 109:15–23. 2018. | |
Xue X, Wang X, Zhao Y, Hu R and Qin L: Exosomal miR-93 promotes proliferation and invasion in hepatocellular carcinoma by directly inhibiting TIMP2/TP53INP1/CDKN1A. Biochem Biophys Res Commun. 502:515–521. 2018. View Article : Google Scholar : PubMed/NCBI | |
Wang Q, Wang G, Niu L, Zhao S, Li J, Zhang Z, Jiang H, Zhang Q, Wang H, Sun P, et al: Exosomal MiR-1290 promotes angiogenesis of hepatocellular carcinoma via targeting SMEK1. J Oncol. 2021:66177002021.PubMed/NCBI | |
Ouyang Y, Tang Y, Fu L, Peng S, Wu W, Tan D and Fu X: Exosomes secreted by chronic hepatitis B patients with PNALT and liver inflammation grade ≥ A2 promoted the progression of liver cancer by transferring miR-25-3p to inhibit the co-expression of TCF21 and HHIP. Cell Prolif. 53:e128332020. View Article : Google Scholar | |
Shi Y, Yang X, Xue X, Sun D, Cai P, Song Q, Zhang B and Qin L: HANR promotes lymphangiogenesis of hepatocellular carcinoma via secreting miR-296 exosome and regulating EAG1/VEGFA signaling in HDLEC cells. J Cell Biochem. 120:17699–17708. 2019. View Article : Google Scholar : PubMed/NCBI | |
Xiong L, Zhen S, Yu Q and Gong Z: HCV-E2 inhibits hepatocellular carcinoma metastasis by stimulating mast cells to secrete exosomal shuttle microRNAs. Oncol Lett. 14:2141–2146. 2017. View Article : Google Scholar : PubMed/NCBI | |
Chen W, Huang L, Liang J, Ye Y, He S and Niu J: Hepatocellular carcinoma cells-derived exosomal microRNA-378b enhances hepatocellular carcinoma angiogenesis. Life Sci. 273:1191842021. View Article : Google Scholar : PubMed/NCBI | |
Fang JH, Zhang ZJ, Shang LR, Luo YW, Lin YF, Yuan Y and Zhuang SM: Hepatoma cell-secreted exosomal microRNA-103 increases vascular permeability and promotes metastasis by targeting junction proteins. Hepatology. 68:1459–1475. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhang Z, Li X, Sun W, Yue S, Yang J, Li J, Ma B, Wang J, Yang X, Pu M, et al: Loss of exosomal miR-320a from cancer-associated fibroblasts contributes to HCC proliferation and metastasis. Cancer Lett. 397:33–42. 2017. View Article : Google Scholar : PubMed/NCBI | |
Bai ZZ, Li HY, Li CH, Sheng CL and Zhao XN: M1 macrophage-derived exosomal MicroRNA-326 suppresses hepatocellular carcinoma cell progression via mediating NF-κB signaling pathway. Nanoscale Res Lett. 15:2212020. View Article : Google Scholar | |
Chen QL, Xie CF, Feng KL, Cui DY, Sun SL, Zhang JC, Xiong CM, Huang JH and Chong Z: microRNAs carried by exosomes promote epithelial-mesenchymal transition and metastasis of liver cancer cells. Am J Transl Res. 12:6811–6826. 2020.PubMed/NCBI | |
Fan F, Chen K, Lu X, Li A, Liu C and Wu B: Dual targeting of PD-L1 and PD-L2 by PCED1B-AS1 via sponging hsa-miR-194-5p induces immunosuppression in hepatocellular carcinoma. Hepatol Int. 15:444–458. 2021. View Article : Google Scholar | |
Wang LP, Lin J, Ma XQ, Xu DY, Shi CF, Wang W and Jiang XJ: Exosomal DLX6-AS1 from hepatocellular carcinoma cells induces M2 macrophage polarization to promote migration and invasion in hepatocellular carcinoma through microRNA-15a-5p/CXCL17 axis. J Exp Clin Cancer Res. 40:1772021. View Article : Google Scholar : PubMed/NCBI | |
Sun L, Su Y, Liu X, Xu M, Chen X, Zhu Y, Guo Z, Bai T, Dong L, Wei C, et al: Serum and exosome long non coding RNAs as potential biomarkers for hepatocellular carcinoma. J Cancer. 9:2631–2639. 2018. View Article : Google Scholar : PubMed/NCBI | |
Wang J, Pu J, Zhang Y, Yao T, Luo Z, Li W, Xu G, Liu J, Wei W and Deng Y: Exosome-transmitted long non-coding RNA SENP3-EIF4A1 suppresses the progression of hepatocellular carcinoma. Aging (Albany NY). 12:11550–11567. 2020. View Article : Google Scholar | |
Li X and Li N: LINC ROR from hepatocarcinoma cell-derived exosomes modulates inflammation in human macrophages. Sichuan Da Xue Xue Bao Yi Xue Ban. 50:177–181. 2019.In Chinese. PubMed/NCBI | |
Li B, Mao R, Liu C, Zhang W, Tang Y and Guo Z: LncRNA FAL1 promotes cell proliferation and migration by acting as a CeRNA of miR-1236 in hepatocellular carcinoma cells. Life Sci. 197:122–129. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhang PF, Gao C, Huang XY, Lu JC, Guo XJ, Shi GM, Cai JB and Ke AW: Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma. Mol Cancer. 19:1102020. View Article : Google Scholar : PubMed/NCBI | |
Su Y, Lv X, Yin W, Zhou L, Hu Y, Zhou A and Qi F: CircRNA Cdr1as functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression. Aging (Albany NY). 11:8183–8203. 2019. View Article : Google Scholar | |
Xu J, Ji L, Liang Y, Wan Z, Zheng W, Song X, Gorshkov K, Sun Q, Lin H, Zheng X, et al: CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1. Signal Transduct Target Ther. 5:2982020. View Article : Google Scholar : PubMed/NCBI | |
Zhu C, Su Y, Liu L, Wang S, Liu Y and Wu J: Circular RNA hsa_circ_0004277 stimulates malignant phenotype of hepatocellular carcinoma and epithelial-mesenchymal transition of peripheral cells. Front Cell Dev Biol. 8:5855652021. View Article : Google Scholar : PubMed/NCBI | |
Yu Y, Bian L, Liu R, Wang Y and Xiao X: Circular RNA hsa_circ_0061395 accelerates hepatocellular carcinoma progression via regulation of the miR-877-5p/PIK3R3 axis. Cancer Cell Int. 21:102021. View Article : Google Scholar : PubMed/NCBI | |
Li Y, Zang H, Zhang X and Huang G: Exosomal circ-ZNF652 promotes cell proliferation, migration, invasion and glycolysis in hepatocellular carcinoma via miR-29a-3p/GUCD1 axis. Cancer Manag Res. 12:7739–7751. 2020. View Article : Google Scholar : PubMed/NCBI | |
Hu K, Li NF, Li JR, Chen ZG, Wang JH and Sheng LQ: Exosome circCMTM3 promotes angiogenesis and tumorigenesis of hepatocellular carcinoma through miR-3619-5p/SOX9. Hepatol Res. 51:1139–1152. 2021. View Article : Google Scholar : PubMed/NCBI | |
Liu D, Kang H, Gao M, Jin L, Zhang F, Chen D, Li M and Xiao L: Exosome-transmitted circ_MMP2 promotes hepatocellular carcinoma metastasis by upregulating MMP2. Mol Oncol. 14:1365–1380. 2020. View Article : Google Scholar : PubMed/NCBI | |
Wang G, Liu W, Zou Y, Wang G, Deng Y, Luo J, Zhang Y, Li H, Zhang Q, Yang Y and Chen G: Three isoforms of exosomal circPTGR1 promote hepatocellular carcinoma metastasis via the miR449a-MET pathway. EBioMedicine. 40:432–445. 2019. View Article : Google Scholar : PubMed/NCBI | |
Chen W, Quan Y, Fan S, Wang H, Liang J, Huang L, Chen L, Liu Q, He P and Ye Y: Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression. Cancer Lett. 475:119–128. 2020. View Article : Google Scholar : PubMed/NCBI | |
Huang C, Yu W, Wang Q, Huang T and Ding Y: CircANTXR1 contributes to the malignant progression of hepatocellular carcinoma by promoting proliferation and metastasis. J Hepatocell Carcinoma. 8:1339–1353. 2021. View Article : Google Scholar : PubMed/NCBI | |
Dai W, Wang Y, Yang T, Wang J, Wu W and Gu J: Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals. Cell Commun Signal. 17:1132019. View Article : Google Scholar : PubMed/NCBI | |
Huang A, Dong J, Li S, Wang C, Ding H, Li H, Su X, Ge X, Sun L, Bai C, et al: Exosomal transfer of vasorin expressed in hepatocellular carcinoma cells promotes migration of human umbilical vein endothelial cells. Int J Biol Sci. 11:961–969. 2015. View Article : Google Scholar : PubMed/NCBI | |
Cheng Z, Lei Z, Yang P, Si A, Xiang D, Tang X, Guo G, Zhou J and Hüser N: Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways. Mol Carcinog. 58:1389–1399. 2019. View Article : Google Scholar : PubMed/NCBI | |
Li M, Lu Y, Xu Y, Wang J, Zhang C, Du Y, Wang L, Li L, Wang B, Shen J, et al: Horizontal transfer of exosomal CXCR4 promotes murine hepatocarcinoma cell migration, invasion and lymphangiogenesis. Gene. 676:101–109. 2018. View Article : Google Scholar : PubMed/NCBI | |
Xia Y, Zhen L, Li H, Wang S, Chen S, Wang C and Yang X: MIRLET7BHG promotes hepatocellular carcinoma progression by activating hepatic stellate cells through exosomal SMO to trigger Hedgehog pathway. Cell Death Dis. 12:3262021. View Article : Google Scholar : PubMed/NCBI | |
Fu Q, Zhang Q, Lou Y, Yang J, Nie G, Chen Q, Chen Y, Zhang J, Wang J, Wei T, et al: Primary tumor-derived exosomes facilitate metastasis by regulating adhesion of circulating tumor cells via SMAD3 in liver cancer. Oncogene. 37:6105–6118. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhou Y, Zhang Y, Gong H, Luo S and Cui Y: The role of exosomes and their applications in cancer. Int J Mol Sci. 22:122042021. View Article : Google Scholar : PubMed/NCBI | |
Wang H, Lu Z and Zhao X: Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer. J Hematol Oncol. 12:1332019. View Article : Google Scholar : PubMed/NCBI | |
Cao LQ, Yang XW, Chen YB, Zhang DW, Jiang XF and Xue P: Exosomal miR-21 regulates the TETs/PTENp1/PTEN pathway to promote hepatocellular carcinoma growth. Mol Cancer. 18:1482019. View Article : Google Scholar : PubMed/NCBI | |
Fu X, Tang Y, Wu W, Ouyang Y, Tan D and Huang Y: Exosomal microRNA-25 released from cancer cells targets SIK1 to promote hepatocellular carcinoma tumorigenesis. Dig Liver Dis. S1590-8658(21): 00385–6. 2021.Epub ahead of print. | |
Huang X, Sun L, Wen S, Deng D, Wan F, He X, Tian L, Liang L, Wei C, Gao K, et al: RNA sequencing of plasma exosomes revealed novel functional long noncoding RNAs in hepatocellular carcinoma. Cancer Sci. 111:3338–3349. 2020. View Article : Google Scholar : PubMed/NCBI | |
Jiang K, Dong C, Yin Z, Li R, Mao J, Wang C, Zhang J, Gao Z, Liang R, Wang Q and Wang L: Exosome-derived ENO1 regulates integrin α6β4 expression and promotes hepatocellular carcinoma growth and metastasis. Cell Death Dis. 11:9722020. View Article : Google Scholar | |
Lai Z, Wei T, Li Q, Wang X, Zhang Y and Zhang S: Exosomal circFBLIM1 promotes hepatocellular carcinoma progression and glycolysis by regulating the miR-338/LRP6 axis. Cancer Biother Radiopharm. Sep 9–2020.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI | |
Ma YS, Liu JB, Lin L, Zhang H, Wu JJ, Shi Y, Jia CY, Zhang DD, Yu F, Wang HM, et al: Exosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4. Cell Death Discov. 7:2242021. View Article : Google Scholar : PubMed/NCBI | |
Yin C, Han Q, Xu D, Zheng B, Zhao X and Zhang J: SALL4-mediated upregulation of exosomal miR-146a-5p drives T-cell exhaustion by M2 tumor-associated macrophages in HCC. Oncoimmunology. 8:16014792019. View Article : Google Scholar : PubMed/NCBI | |
Conigliaro A, Costa V, Lo Dico A, Saieva L, Buccheri S, Dieli F, Manno M, Raccosta S, Mancone C, Tripodi M, et al: CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA. Mol Cancer. 14:1552015. View Article : Google Scholar : PubMed/NCBI | |
Li R, Wang Y, Zhang X, Feng M, Ma J, Li J, Yang X, Fang F, Xia Q, Zhang Z, et al: Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis. Mol Cancer. 18:182019. View Article : Google Scholar : PubMed/NCBI | |
Tian XP, Wang CY, Jin XH, Li M, Wang FW, Huang WJ, Yun JP, Xu RH, Cai QQ and Xie D: Acidic microenvironment up-regulates exosomal miR-21 and miR-10b in early-stage hepatocellular carcinoma to promote cancer cell proliferation and metastasis. Theranostics. 9:1965–1979. 2019. View Article : Google Scholar : PubMed/NCBI | |
Liu H, Chen W, Zhi X, Chen EJ, Wei T, Zhang J, Shen J, Hu LQ, Zhao B, Feng XH, et al: Tumor-derived exosomes promote tumor self-seeding in hepatocellular carcinoma by transferring miRNA-25-5p to enhance cell motility. Oncogene. 37:4964–4978. 2018. View Article : Google Scholar : PubMed/NCBI | |
Liu G, Ouyang X, Sun Y, Xiao Y, You B, Gao Y, Yeh S, Li Y and Chang C: The miR-92a-2-5p in exosomes from macrophages increases liver cancer cells invasion via altering the AR/PHLPP/p-AKT/β-catenin signaling. Cell Death Differ. 27:3258–3272. 2020. View Article : Google Scholar : PubMed/NCBI | |
Liu C, Zhou X, Long Q, Zeng H, Sun Q, Chen Y, Wu D and Liu L: Small extracellular vesicles containing miR-30a-3p attenuate the migration and invasion of hepatocellular carcinoma by targeting SNAP23 gene. Oncogene. 40:233–245. 2021. View Article : Google Scholar | |
Zeng Y, Yao X, Liu X, He X, Li L, Liu X, Yan Z, Wu J and Fu BM: Anti-angiogenesis triggers exosomes release from endothelial cells to promote tumor vasculogenesis. J Extracell Vesicles. 8:16298652019. View Article : Google Scholar : PubMed/NCBI | |
Wu Q, Zhou L, Lv D, Zhu X and Tang H: Exosome-mediated communication in the tumor microenvironment contributes to hepatocellular carcinoma development and progression. J Hematol Oncol. 12:532019. View Article : Google Scholar : PubMed/NCBI | |
Yang Y, Han Q, Hou Z, Zhang C, Tian Z and Zhang J: Exosomes mediate hepatitis B virus (HBV) transmission and NK-cell dysfunction. Cell Mol Immunol. 14:465–475. 2017. View Article : Google Scholar : | |
Wu W, Wu D, Yan W, Wang Y, You J, Wan X, Xi D, Luo X, Han M and Ning Q: Interferon-induced macrophage-derived exosomes mediate antiviral activity against hepatitis B virus through miR-574-5p. J Infect Dis. 223:686–698. 2021. View Article : Google Scholar | |
Liu QM, He YY, Liu LL and Wang LK: Exosomal lncRNA HOTTIP mediates antiviral effect of tenofovir alafenamide (TAF) on HBV infection. J Inflamm Res. 14:5489–5500. 2021. View Article : Google Scholar : PubMed/NCBI | |
Lu J, Wu J, Xie F, Tian J, Tang X, Guo H, Ma J, Xu P, Mao L, Xu H and Wang S: CD4+ T cell-released extracellular vesicles potentiate the efficacy of the HBsAg vaccine by enhancing B cell responses. Adv Sci (Weinh). 6:18022192019. View Article : Google Scholar | |
Wei Y, Tang X, Ren Y, Yang Y, Song F, Fu J, Liu S, Yu M, Chen L, Wang S, et al: An RNA-RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity. Signal Transduct Target Ther. 6:4212021. View Article : Google Scholar : PubMed/NCBI | |
Zhou Y, Ren H, Dai B, Li J, Shang L, Huang J and Shi X: Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts. J Exp Clin Cancer Res. 37:3242018. View Article : Google Scholar : PubMed/NCBI | |
Fang T, Lv H, Lv G, Li T, Wang C, Han Q, Yu L, Su B, Guo L, Huang S, et al: Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer. Nat Commun. 9:1912018. View Article : Google Scholar : PubMed/NCBI | |
Lou G, Song X, Yang F, Wu S, Wang J, Chen Z and Liu Y: Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma. J Hematol Oncol. 8:1222015. View Article : Google Scholar : PubMed/NCBI | |
Lin M, Liao W, Dong M, Zhu R, Xiao J, Sun T, Chen Z, Wu B and Jin J: Exosomal neutral sphingomyelinase 1 suppresses hepatocellular carcinoma via decreasing the ratio of sphingomyelin/ceramide. FEBS J. 285:3835–3848. 2018. View Article : Google Scholar : PubMed/NCBI | |
Lin H, Zhang R, Wu W and Lei L: miR-4454 promotes hepatic carcinoma progression by targeting Vps4A and Rab27A. Oxid Med Cell Longev. 2021:92304352021. View Article : Google Scholar : PubMed/NCBI | |
Sun JF, Zhang D, Gao CJ, Zhang YW and Dai QS: Exosome-mediated MiR-155 transfer contributes to hepatocellular carcinoma cell proliferation by targeting PTEN. Med Sci Monit Basic Res. 25:218–228. 2019. View Article : Google Scholar : PubMed/NCBI | |
Li YH, Lv MF, Lu MS and Bi JP: Bone marrow mesenchymal stem cell-derived exosomal MiR-338-3p represses progression of hepatocellular carcinoma by targeting ETS1. J Biol Regul Homeost Agents. 35:617–627. 2021.PubMed/NCBI | |
Wang D, Xing N, Yang T, Liu J, Zhao H, He J, Ai Y and Yang J: Exosomal lncRNA H19 promotes the progression of hepatocellular carcinoma treated with Propofol via miR-520a-3p/LIMK1 axis. Cancer Med. 9:7218–7230. 2020. View Article : Google Scholar : PubMed/NCBI | |
Li S, Qi Y, Huang Y, Guo Y, Huang T and Jia L: Exosome-derived SNHG16 sponging miR-4500 activates HUVEC angiogenesis by targeting GALNT1 via PI3K/Akt/mTOR pathway in hepatocellular carcinoma. J Physiol Biochem. 77:667–682. 2021. View Article : Google Scholar : PubMed/NCBI | |
Lin XJ, Fang JH, Yang XJ, Zhang C, Yuan Y, Zheng L and Zhuang SM: Hepatocellular carcinoma cell-secreted exosomal MicroRNA-210-promotes angiogenesis in vitro and in vivo. Mol Ther Nucleic Acids. 11:243–252. 2018. View Article : Google Scholar : PubMed/NCBI | |
Dong SS, Dong DD, Yang ZF, Zhu GQ, Gao DM, Chen J, Zhao Y and Liu BB: Exosomal miR-3682-3p suppresses angiogenesis by targeting ANGPT1 via the RAS-MEK1/2ERK1/2 pathway in hepatocellular carcinoma. Front Cell Dev Biol. 9:6333582021. View Article : Google Scholar | |
Huang XY, Huang ZL, Huang J, Xu B, Huang XY, Xu YH, Zhou J and Tang ZY: Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis. J Exp Clin Cancer Res. 39:202020. View Article : Google Scholar : PubMed/NCBI | |
Yang B, Feng X, Liu H, Tong R, Wu J, Li C, Yu H, Chen Y, Cheng Q, Chen J, et al: High-metastatic cancer cells derived exosomal miR92a-3p promotes epithelial-mesenchymal transition and metastasis of low-metastatic cancer cells by regulating PTEN/Akt pathway in hepatocellular carcinoma. Oncogene. 39:6529–6543. 2020. View Article : Google Scholar : PubMed/NCBI | |
Chen L, Guo P, He Y, Chen Z, Chen L, Luo Y, Qi L, Liu Y, Wu Q, Cui Y, et al: HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK/ERK signalling pathway. Cell Death Dis. 9:5132018. View Article : Google Scholar : PubMed/NCBI | |
Lin Q, Zhou CR, Bai MJ, Zhu D, Chen JW, Wang HF, Li MA, Wu C, Li ZR and Huang MS: Exosome-mediated miRNA delivery promotes liver cancer EMT and metastasis. Am J Transl Res. 12:1080–1095. 2020.PubMed/NCBI | |
Zhuo C, Yi T, Pu J, Cen X, Zhou Y, Feng S, Wei C, Chen P, Wang W, Bao C, et al: Exosomal linc-FAM138B from cancer cells alleviates hepatocellular carcinoma progression via regulating miR-765. Aging (Albany NY). 12:26236–26247. 2020. View Article : Google Scholar | |
Wu J, Gao W, Tang Q, Yu Y, You W, Wu Z, Fan Y, Zhang L, Wu C, Han G, et al: M2 macrophage-derived exosomes facilitate HCC metastasis by transferring αM β2 integrin to tumor cells. Hepatology. 73:1365–1380. 2021. View Article : Google Scholar | |
Wang Y, Gao R, Li J, Tang S and Li S, Tong Q and Li S: Downregulation of hsa_circ_0074854 suppresses the migration and invasion in hepatocellular carcinoma via interacting with HuR and via suppressing exosomes-mediated macrophage M2 polarization. Int J Nanomedicine. 16:2803–2818. 2021. View Article : Google Scholar : PubMed/NCBI | |
Li X, Lei Y, Wu M and Li N: Regulation of macrophage activation and polarization by HCC-derived exosomal lncRNA TUC339. Int J Mol Sci. 19:29582018. View Article : Google Scholar : | |
Ozga AJ, Chow MT and Luster AD: Chemokines and the immune response to cancer. Immunity. 54:859–874. 2021. View Article : Google Scholar : PubMed/NCBI | |
Syn NL, Wang L, Chow EK, Lim CT and Goh BC: Exosomes in cancer nanomedicine and immunotherapy: Prospects and challenges. Trends Biotechnol. 35:665–676. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wang X, Shen H, Zhangyuan G, Huang R, Zhang W, He Q, Jin K, Zhuo H, Zhang Z, Wang J, et al: 14-3-3ζ delivered by hepatocellular carcinoma-derived exosomes impaired anti-tumor function of tumor-infiltrating T lymphocytes. Cell Death Dis. 9:1592018. View Article : Google Scholar | |
Ye L, Zhang Q, Cheng Y, Chen X, Wang G, Shi M, Zhang T, Cao Y, Pan H, Zhang L, et al: Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1+ regulatory B cell expansion. J Immunother Cancer. 6:1452018. View Article : Google Scholar | |
Li H, Yang C, Shi Y and Zhao L: Exosomes derived from siRNA against GRP78 modified bone-marrow-derived mesenchymal stem cells suppress Sorafenib resistance in hepatocellular carcinoma. J Nanobiotechnology. 16:1032018. View Article : Google Scholar : PubMed/NCBI | |
Liu Y, Tan J, Ou S, Chen J and Chen L: Adipose-derived exosomes deliver miR-23a/b to regulate tumor growth in hepatocellular cancer by targeting the VHL/HIF axis. J Physiol Biochem. 75:391–401. 2019. View Article : Google Scholar : PubMed/NCBI | |
Huang H, Hou J, Liu K, Liu Q, Shen L, Liu B, Lu Q, Zhang N, Che L, Li J, et al: RAB27A-dependent release of exosomes by liver cancer stem cells induces Nanog expression in their differentiated progenies and confers regorafenib resistance. J Gastroenterol Hepatol. 36:3429–3437. 2021. View Article : Google Scholar : PubMed/NCBI | |
Xu Y, Lai Y, Cao L, Li Y, Chen G, Chen L, Weng H, Chen T, Wang L and Ye Y: Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-451a represses epithelial-mesenchymal transition of hepatocellular carcinoma cells by inhibiting ADAM10. RNA Biol. 18:14232021. View Article : Google Scholar | |
Wang G, Zhao W, Wang H, Qiu G, Jiang Z, Wei G and Li X: Exosomal MiR-744 inhibits proliferation and sorafenib chemoresistance in hepatocellular carcinoma by targeting PAX2. Med Sci Monit. 25:7209–7217. 2019. View Article : Google Scholar : PubMed/NCBI | |
Pinyol R, Montal R, Bassaganyas L, Sia D, Takayama T, Chau GY, Mazzaferro V, Roayaie S, Lee HC, Kokudo N, et al: Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial. Gut. 68:1065–1075. 2019. View Article : Google Scholar | |
Zhang Y, Xi H, Nie X, Zhang P, Lan N, Lu Y, Liu J and Yuan W: Assessment of miR-212 and other biomarkers in the diagnosis and treatment of HBV-infection-related liver diseases. Curr Drug Metab. 20:785–798. 2019. View Article : Google Scholar : PubMed/NCBI | |
Guo S, Hu C, Zhai X and Sun D: Circular RNA 0006602 in plasma exosomes: A new potential diagnostic biomarker for hepatocellular carcinoma. Am J Transl Res. 13:6001–6015. 2021.PubMed/NCBI | |
De Stefano F, Chacon E, Turcios L, Marti F and Gedaly R: Novel biomarkers in hepatocellular carcinoma. Dig Liver Dis. 50:1115–1123. 2018. View Article : Google Scholar : PubMed/NCBI | |
Galle PR, Foerster F, Kudo M, Chan SL, Llovet JM, Qin S, Schelman WR, Chintharlapalli S, Abada PB, Sherman M and Zhu AX: Biology and significance of alpha-fetoprotein in hepatocellular carcinoma. Liver Int. 39:2214–2229. 2019. View Article : Google Scholar : PubMed/NCBI | |
Ahn JC, Teng PC, Chen PJ, Posadas E, Tseng HR, Lu SC and Yang JD: Detection of circulating tumor cells and their implications as a biomarker for diagnosis, prognostication, and therapeutic monitoring in hepatocellular carcinoma. Hepatology. 73:422–436. 2021. View Article : Google Scholar | |
von Felden J, Garcia-Lezana T, Schulze K, Losic B and Villanueva A: Liquid biopsy in the clinical management of hepatocellular carcinoma. Gut. 69:2025–2034. 2020. View Article : Google Scholar : PubMed/NCBI | |
Mjelle R, Dima SO, Bacalbasa N, Chawla K, Sorop A, Cucu D, Herlea V, Sætrom P and Popescu I: Comprehensive transcriptomic analyses of tissue, serum, and serum exosomes from hepatocellular carcinoma patients. BMC Cancer. 19:10072019. View Article : Google Scholar : PubMed/NCBI | |
Sheng LQ, Li JR, Qin H, Liu L, Zhang DD, Zhang Q, Huang ML, Li XL, Xu XY, Wei YN, et al: Blood exosomal micro ribonucleic acid profiling reveals the complexity of hepatocellular carcinoma and identifies potential biomarkers for differential diagnosis. World J Gastrointest Oncol. 12:1195–1208. 2020. View Article : Google Scholar : PubMed/NCBI | |
Thind A and Wilson C: Exosomal miRNAs as cancer biomarkers and therapeutic targets. J Extracell Vesicles. 5:312922016. View Article : Google Scholar : PubMed/NCBI | |
Salehi M and Sharifi M: Exosomal miRNAs as novel cancer biomarkers: Challenges and opportunities. J Cell Physiol. 233:6370–6380. 2018. View Article : Google Scholar : PubMed/NCBI | |
Fitts CA, Ji N, Li Y and Tan C: Exploiting exosomes in cancer liquid biopsies and drug delivery. Adv Healthc Mater. 8:e18012682019. View Article : Google Scholar : PubMed/NCBI | |
Caradec J, Kharmate G, Hosseini-Beheshti E, Adomat H, Gleave M and Guns E: Reproducibility and efficiency of serum-derived exosome extraction methods. Clin Biochem. 47:1286–1292. 2014. View Article : Google Scholar : PubMed/NCBI | |
Ge Y, Mu W, Ba Q, Li J, Jiang Y, Xia Q and Wang H: Hepatocellular carcinoma-derived exosomes in organotropic metastasis, recurrence and early diagnosis application. Cancer Lett. 477:41–48. 2020. View Article : Google Scholar : PubMed/NCBI | |
Zhang C, Yang X, Qi Q, Gao Y, Wei Q and Han S: lncRNA-HEIH in serum and exosomes as a potential biomarker in the HCV-related hepatocellular carcinoma. Cancer Biomark. 21:651–659. 2018. View Article : Google Scholar | |
Lyu L, Yang W, Yao J, Wang H, Zhu J, Jin A, Liu T, Wang B, Zhou J, Fan J, et al: The diagnostic value of plasma exosomal hsa_circ_0070396 for hepatocellular carcinoma. Biomark Med. 15:359–371. 2021. View Article : Google Scholar : PubMed/NCBI | |
Cho HJ, Baek GO, Seo CW, Ahn HR, Sung S, Son JA, Kim SS, Cho SW, Jang JW, Nam SW, et al: Exosomal microRNA-4661-5p-based serum panel as a potential diagnostic biomarker for early-stage hepatocellular carcinoma. Cancer Med. 9:5459–5472. 2020. View Article : Google Scholar : PubMed/NCBI | |
Cui Y, Xu HF, Liu MY, Xu YJ, He JC, Zhou Y and Cang SD: Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value. World J Gastroenterol. 25:1890–1898. 2019. View Article : Google Scholar : PubMed/NCBI | |
Fründt T, Krause L, Hussey E, Steinbach B, Köhler D, von Felden J, Schulze K, Lohse AW, Wege H and Schwarzenbach H: Diagnostic and prognostic value of miR-16, miR-146a, miR-192 and miR-221 in exosomes of hepatocellular carcinoma and liver cirrhosis patients. Cancers (Basel). 13:24842021. View Article : Google Scholar | |
Wang S, Yang Y, Sun L, Qiao G, Song Y and Liu B: Exosomal MicroRNAs as liquid biopsy biomarkers in hepatocellular carcinoma. Onco Targets Ther. 13:2021–2030. 2020. View Article : Google Scholar : PubMed/NCBI | |
Liu WH, Ren LN, Wang X, Wang T, Zhang N, Gao Y, Luo H, Navarro-Alvarez N and Tang LJ: Combination of exosomes and circulating microRNAs may serve as a promising tumor marker complementary to alpha-fetoprotein for early-stage hepatocellular carcinoma diagnosis in rats. J Cancer Res Clin Oncol. 141:1767–1778. 2015. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Zhang C, Zhang P, Guo G, Jiang T, Zhao X, Jiang J, Huang X, Tong H and Tian Y: Serum exosomal microRNAs combined with alpha-fetoprotein as diagnostic markers of hepatocellular carcinoma. Cancer Med. 7:1670–1679. 2018. View Article : Google Scholar : PubMed/NCBI | |
Cui Z, Li Y, Gao Y, Kong L, Lin Y and Chen Y: Cancer-testis antigen lactate dehydrogenase C4 in hepatocellular carcinoma: A promising biomarker for early diagnosis, efficacy evaluation and prognosis prediction. Aging (Albany NY). 12:19455–19467. 2020.Epub ahead of print. View Article : Google Scholar | |
Kim SS, Baek GO, Ahn HR, Sung S, Seo CW, Cho HJ, Nam SW, Cheong JY and Eun JW: Serum small extracellular vesicle-derived LINC00853 as a novel diagnostic marker for early hepatocellular carcinoma. Mol Oncol. 14:2646–2659. 2020. View Article : Google Scholar : PubMed/NCBI | |
Sanchez JI, Jiao J, Kwan SY, Veillon L, Warmoes MO, Tan L, Odewole M, Rich NE, Wei P, Lorenzi PL, et al: Lipidomic profiles of plasma exosomes identify candidate biomarkers for early detection of hepatocellular carcinoma in patients with cirrhosis. Cancer Prev Res (Phila). 14:955–962. 2021. View Article : Google Scholar | |
Li W, Ding X, Wang S, Xu L, Yin T, Han S, Geng J and Sun W: Downregulation of serum exosomal miR-320d predicts poor prognosis in hepatocellular carcinoma. J Clin Lab Anal. 34:e232392020.PubMed/NCBI | |
Qu Z, Wu J, Wu J, Ji A, Qiang G, Jiang Y, Jiang C and Ding Y: Exosomal miR-665 as a novel minimally invasive biomarker for hepatocellular carcinoma diagnosis and prognosis. Oncotarget. 8:80666–80678. 2017. View Article : Google Scholar : PubMed/NCBI | |
Xu H, Chen Y, Dong X and Wang X: Serum exosomal long noncoding RNAs ENSG00000258332.1 and LINC00635 for the diagnosis and prognosis of hepatocellular carcinoma. Cancer Epidemiol Biomarkers Prev. 27:710–716. 2018. View Article : Google Scholar : PubMed/NCBI | |
Cho HJ, Baek GO, Yoon MG, Ahn HR, Son JA, Kim SS, Cheong JY and Eun JW: Overexpressed proteins in HCC cell-derived exosomes, CCT8, and cofilin-1 are potential biomarkers for patients with HCC. Diagnostics (Basel). 11:12212021. View Article : Google Scholar | |
Eun JW, Seo CW, Baek GO, Yoon MG, Ahn HR, Son JA, Sung S, Kim DW, Kim SS, Cho HJ and Cheong JY: Circulating exosomal MicroRNA-1307-5p as a predictor for metastasis in patients with hepatocellular carcinoma. Cancers (Basel). 12:38192020. View Article : Google Scholar | |
Liu W, Hu J, Zhou K, Chen F, Wang Z, Liao B, Dai Z, Cao Y, Fan J and Zhou J: Serum exosomal miR-125b is a novel prognostic marker for hepatocellular carcinoma. Onco Targets Ther. 10:3843–3851. 2017. View Article : Google Scholar : PubMed/NCBI | |
Kim HS, Kim JS, Park NR, Nam H, Sung PS, Bae SH, Choi JY, Yoon SK, Hur W and Jang JW: Exosomal miR-125b exerts anti-metastatic properties and predicts early metastasis of hepatocellular carcinoma. Front Oncol. 11:6372472021. View Article : Google Scholar : PubMed/NCBI | |
Lee YR, Kim G, Tak WY, Jang SY, Kweon YO, Park JG, Lee HW, Han YS, Chun JM, Park SY and Hur K: Circulating exosomal noncoding RNAs as prognostic biomarkers in human hepatocellular carcinoma. Int J Cancer. 144:1444–1452. 2019. View Article : Google Scholar | |
Xu H, Dong X, Chen Y and Wang X: Serum exosomal hnRNPH1 mRNA as a novel marker for hepatocellular carcinoma. Clin Chem Lab Med. 56:479–484. 2018. View Article : Google Scholar | |
Ma D, Gao X, Liu Z, Lu X, Ju H and Zhang N: Exosome-transferred long non-coding RNA ASMTL-AS1 contributes to malignant phenotypes in residual hepatocellular carcinoma after insufficient radiofrequency ablation. Cell Prolif. 53:e127952020. View Article : Google Scholar : PubMed/NCBI | |
Shi M, Jiang Y, Yang L, Yan S, Wang YG and Lu XJ: Decreased levels of serum exosomal miR-638 predict poor prognosis in hepatocellular carcinoma. J Cell Biochem. 119:4711–4716. 2018. View Article : Google Scholar | |
Wang T, Zhu H, Xiao M and Zhou S: Serum exosomal long noncoding RNA CRNDE as a prognostic biomarker for hepatocellular carcinoma. J Clin Lab Anal. 35:e239592021. View Article : Google Scholar : PubMed/NCBI | |
Luo Y, Liu F and Gui R: High expression of circulating exosomal circAKT3 is associated with higher recurrence in HCC patients undergoing surgical treatment. Surg Oncol. 33:276–281. 2020. View Article : Google Scholar : PubMed/NCBI | |
Yokota Y, Noda T, Okumura Y, Kobayashi S, Iwagami Y, Yamada D, Tomimaru Y, Akita H, Gotoh K, Takeda Y, et al: Serum exosomal miR-638 is a prognostic marker of HCC via downregulation of VE-cadherin and ZO-1 of endothelial cells. Cancer Sci. 112:1275–1288. 2021. View Article : Google Scholar : PubMed/NCBI | |
Sugimachi K, Matsumura T, Hirata H, Uchi R, Ueda M, Ueo H, Shinden Y, Iguchi T, Eguchi H, Shirabe K, et al: Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation. Br J Cancer. 112:532–538. 2015. View Article : Google Scholar : PubMed/NCBI | |
Suehiro T, Miyaaki H, Kanda Y, Shibata H, Honda T, Ozawa E, Miuma S, Taura N and Nakao K: Serum exosomal microRNA-122 and microRNA-21 as predictive biomarkers in transarterial chemoembolization-treated hepatocellular carcinoma patients. Oncol Lett. 16:3267–3273. 2018.PubMed/NCBI | |
Wang SC, Li CY, Chang WT, Cheng WC, Yen CH, Tu WY, Lin ZY, Lin CC, Yeh ML, Huang CF, et al: Exosome-derived differentiation antagonizing non-protein coding RNA with risk of hepatitis C virus-related hepatocellular carcinoma recurrence. Liver Int. 41:956–968. 2021. View Article : Google Scholar | |
Qin L, Zhan Z, Wei C, Li X, Zhang T and Li J: Has-circRNA-G004213 promotes cisplatin sensitivity by regulating miR-513b-5p/PRPF39 in liver cancer. Mol Med Rep. 23:4212021. View Article : Google Scholar | |
Ghosh S, Bhowmik S, Majumdar S, Goswami A, Chakraborty J, Gupta S, Aggarwal S, Ray S, Chatterjee R, Bhattacharyya S, et al: The exosome encapsulated microRNAs as circulating diagnostic marker for hepatocellular carcinoma with low alpha-fetoprotein. Int J Cancer. 147:2934–2947. 2020. View Article : Google Scholar : PubMed/NCBI | |
Sun XH, Wang YT, Li GF, Zhang N and Fan L: Serum-derived three-circRNA signature as a diagnostic biomarker for hepatocellular carcinoma. Cancer Cell Int. 20:2262020. View Article : Google Scholar : PubMed/NCBI | |
Kim SS, Baek GO, Son JA, Ahn HR, Yoon MK, Cho HJ, Yoon JH, Nam SW, Cheong JY and Eun JW: Early detection of hepatocellular carcinoma via liquid biopsy: Panel of small extracellular vesicle-derived long noncoding RNAs identified as markers. Mol Oncol. 15:2715–2731. 2021. View Article : Google Scholar : PubMed/NCBI | |
Huang C, Tang S, Shen D, Li X, Liang L, Ding Y and Xu B: Circulating plasma exosomal miRNA profiles serve as potential metastasis-related biomarkers for hepatocellular carcinoma. Oncol Lett. 21:1682021. View Article : Google Scholar : PubMed/NCBI | |
Itami-Matsumoto S, Hayakawa M, Uchida-Kobayashi S, Enomoto M, Tamori A, Mizuno K, Toyoda H, Tamura T, Akutsu T, Ochiya T, et al: Circulating exosomal miRNA profiles predict the occurrence and recurrence of hepatocellular carcinoma in patients with direct-acting antiviral-induced sustained viral response. Biomedicines. 7:872019. View Article : Google Scholar | |
Sorop A, Iacob R, Iacob S, Constantinescu D, Chitoiu L, Fertig TE, Dinischiotu A, Chivu-Economescu M, Bacalbasa N, Savu L, et al: Plasma small extracellular vesicles derived miR-21-5p and miR-92a-3p as potential biomarkers for hepatocellular carcinoma screening. Front Genet. 11:7122020. View Article : Google Scholar : PubMed/NCBI | |
Xu LX, He MH, Dai ZH, Yu J, Wang JG, Li XC, Jiang BB, Ke ZF, Su TH, Peng ZW, et al: Genomic and transcriptional heterogeneity of multifocal hepatocellular carcinoma. Ann Oncol. 30:990–997. 2019. View Article : Google Scholar : PubMed/NCBI | |
Huang A, Yang XR, Chung WY, Dennison AR and Zhou J: Targeted therapy for hepatocellular carcinoma. Signal Transduct Target Ther. 5:1462020. View Article : Google Scholar : PubMed/NCBI | |
Yang Y, Hong Y, Cho E, Kim GB and Kim IS: Extracellular vesicles as a platform for membrane-associated therapeutic protein delivery. J Extracell Vesicles. 7:14401312018. View Article : Google Scholar : PubMed/NCBI | |
Ha D, Yang N and Nadithe V: Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: Current perspectives and future challenges. Acta Pharm Sin B. 6:287–296. 2016. View Article : Google Scholar : PubMed/NCBI | |
Ding J, Wang J and Chen J: Exosomes as therapeutic vehicles in liver diseases. Ann Transl Med. 9:7352021. View Article : Google Scholar : PubMed/NCBI | |
Tai YL, Chen KC, Hsieh JT and Shen TL: Exosomes in cancer development and clinical applications. Cancer Sci. 109:2364–2374. 2018. View Article : Google Scholar : PubMed/NCBI | |
Lowry MC, Gallagher WM and O'Driscoll L: The role of exosomes in breast cancer. Clin Chem. 61:1457–1465. 2015. View Article : Google Scholar : PubMed/NCBI | |
Xue D, Han J, Liu Y, Tuo H and Peng Y: Current perspectives on exosomes in the diagnosis and treatment of hepatocellular carcinoma (review). Cancer Biol Ther. 22:279–290. 2021. View Article : Google Scholar : PubMed/NCBI | |
Khan N, Maurya S, Bammidi S and Jayandharan GR: AAV6 vexosomes mediate robust suicide gene delivery in a murine model of hepatocellular carcinoma. Mol Ther Methods Clin Dev. 17:497–504. 2020. View Article : Google Scholar : PubMed/NCBI | |
Du J, Wan Z, Wang C, Lu F, Wei M, Wang D and Hao Q: Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy. Theranostics. 11:8185–8196. 2021. View Article : Google Scholar : PubMed/NCBI | |
Li I and Nabet BY: Exosomes in the tumor microenvironment as mediators of cancer therapy resistance. Mol Cancer. 18:322019. View Article : Google Scholar : PubMed/NCBI | |
Le Grazie M, Biagini MR, Tarocchi M, Polvani S and Galli A: Chemotherapy for hepatocellular carcinoma: The present and the future. World J Hepatol. 9:907–920. 2017. View Article : Google Scholar : PubMed/NCBI | |
Shi S, Rao Q, Zhang C, Zhang X, Qin Y and Niu Z: Dendritic cells pulsed with exosomes in combination with PD-1 antibody increase the efficacy of sorafenib in hepatocellular carcinoma model. Transl Oncol. 11:250–258. 2018. View Article : Google Scholar : PubMed/NCBI | |
Loch-Neckel G, Matos AT, Vaz AR and Brites D: Challenges in the development of drug delivery systems based on small extracellular vesicles for therapy of brain diseases. Front Pharmacol. 13:8397902022. View Article : Google Scholar : PubMed/NCBI | |
Pospichalova V, Svoboda J, Dave Z, Kotrbova A, Kaiser K, Klemova D, Ilkovics L, Hampl A, Crha I, Jandakova E, et al: Simplified protocol for flow cytometry analysis of fluorescently labeled exosomes and microvesicles using dedicated flow cytometer. J Extracell Vesicles. 4:255302015. View Article : Google Scholar : PubMed/NCBI | |
Zarovni N, Corrado A, Guazzi P, Zocco D, Lari E, Radano G, Muhhina J, Fondelli C, Gavrilova J and Chiesi A: Integrated isolation and quantitative analysis of exosome shuttled proteins and nucleic acids using immunocapture approaches. Methods. 87:46–58. 2015. View Article : Google Scholar : PubMed/NCBI | |
Bala S, Csak T, Momen-Heravi F, Lippai D, Kodys K, Catalano D, Satishchandran A, Ambros V and Szabo G: Biodistribution and function of extracellular miRNA-155 in mice. Sci Rep. 5:107212015. View Article : Google Scholar : PubMed/NCBI | |
Zhou H, Yuen PS, Pisitkun T, Gonzales PA, Yasuda H, Dear JW, Gross P, Knepper MA and Star RA: Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery. Kidney Int. 69:1471–1476. 2006. View Article : Google Scholar : PubMed/NCBI |