Open Access

Exosomal integrins in tumor progression, treatment and clinical prediction (Review)

  • Authors:
    • Yu-Qing Shen
    • Lei Sun
    • Shi-Ming Wang
    • Xian-Yu Zheng
    • Rui Xu
  • View Affiliations

  • Published online on: November 13, 2024     https://doi.org/10.3892/ijo.2024.5706
  • Article Number: 118
  • Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Integrins are a large family of cell adhesion molecules involved in tumor cell differentiation, migration, proliferation and neovascularization. Tumor cell‑derived exosomes carry a large number of integrins, which are closely associated with tumor progression. As crucial mediators of intercellular communication, exosomal integrins have gained attention in the field of cancer biology. The present review examined the regulatory mechanisms of exosomal integrins in tumor cell proliferation, migration and invasion, and emphasized their notable roles in tumor initiation and progression. The potential of exosomal integrins as drug delivery systems in cancer treatment was explored. Additionally, the potential of exosomal integrins in clinical tumor prediction was considered, while summarizing their applications in diagnosis, prognosis assessment and treatment response prediction. Thus, the present review aimed to provide guidance and insights for future basic research and the clinical translation of exosomal integrins. The study of exosomal integrins is poised to offer new perspectives and methods for precise cancer treatment and clinical prediction.
View Figures
View References

Related Articles

Journal Cover

December-2024
Volume 65 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Shen Y, Sun L, Wang S, Zheng X and Xu R: Exosomal integrins in tumor progression, treatment and clinical prediction (Review). Int J Oncol 65: 118, 2024.
APA
Shen, Y., Sun, L., Wang, S., Zheng, X., & Xu, R. (2024). Exosomal integrins in tumor progression, treatment and clinical prediction (Review). International Journal of Oncology, 65, 118. https://doi.org/10.3892/ijo.2024.5706
MLA
Shen, Y., Sun, L., Wang, S., Zheng, X., Xu, R."Exosomal integrins in tumor progression, treatment and clinical prediction (Review)". International Journal of Oncology 65.6 (2024): 118.
Chicago
Shen, Y., Sun, L., Wang, S., Zheng, X., Xu, R."Exosomal integrins in tumor progression, treatment and clinical prediction (Review)". International Journal of Oncology 65, no. 6 (2024): 118. https://doi.org/10.3892/ijo.2024.5706