Journal Articles
Predictive biomarker of neoadjuvant chemoimmunotherapy in resectable non-small cell lung cancer
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Dr Kyoichi Kaira
, 
Gunma University Hospital
, 
Japan
Nowadays, neoadjuvant chemoimmunotherapy is identified as one of perioperative treatment in early stage non-small cell lung cancer (NSCLC). After 3 cycles of platinum-based regimen plus nivolumab administration, the pathological complete response (p-CR) of 24% was observed, compared to 2.2% in chemotherapy alone. However, there was no established biomarker for predicting the p-CR of chemoimmunotherapy. A exploratory investigation suggested the potential of cfDNA as predictor, however, approximately 75% patients had no detection of cfDNA before chemoimmunotherapy administration. Therefore, it is needed to elucidate the presence of some biomarkers for predicting the p-CR or major pathological response (MPR) at early phase after neoadjuvant chemoimmunotherapy initiation in NSCLC. This special issue focus on the predictive biomarkers of neoadjuvant chemoimmunotherapy.
Submission deadline:
15/03/2025